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Abstract #3289

Reliable estimation of kidney filtration rate with DCE-MRI using motion-robust high spatiotemporal resolution Radial VIBE

Sila Kurugol1, Onur Afacan2, Deborah R Stein3, Michael A Ferguson3, Richard S Lee4, Reid Nichols2, Ravi T Seethamraju5, Jeanne S Chow2, and Simon K Warfield6

1Radiology, Boston Children's Hospital and Harvard Medical School, Bosotn, MA, United States, 2Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States, 3Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States, 4Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States, 5Siemens Healthcare, 6Boston Children's Hospital and Harvard Medical School, Boston, MA, United States

Chronic kidney disease poses a significant health burden, and patients benefit from early detection of kidney function. Serum-creatinine based estimation is insensitive to early changes and nuclear medicine studies expose patients to radiation. In this work, we evaluated a novel technique, motion-robust high spatiotemporal resolution Dynamic Radial VIBE (DRV) with compressed sensing, to reconstruct high-quality dynamic image series, and to precisely estimate filtration rate per kidney and per voxel. Our results suggest that, compared to conventional Cartesian VIBE, DRV reconstructs higher quality motion-robust images and results in improved the goodness-of-fit to the tracer kinetic model, reducing RMSE and increasing the precision of filtration rate parameter.

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