Intrinsic conditions leading to renal graft dysfunction have so far been difficult to diagnose non-invasively because of the overlap in symptoms and laboratory metrics. MRI provides an accurate assessment of the morphology of the transplanted kidney, as well as of vascular or obstructive renal disorders. The long-term goal of our study is to validate functional MRI as a “virtual biopsy” by developing a multiparametric MRI protocol using advanced quantitative MRI sequences in renal transplant patients. We report initial results and test-retest repeatability of quantitative mpMRI parameters of diffusion, perfusion and hypoxia in renal allografts.
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