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Abstract #3315

Exploring Lung Inflation Mechanisms with 3D 3He and 129Xe Whole Lung Morphometry Mapping

Ho-Fung Chan1, Juan Parra-Robles1,2, Guilhem J Collier1, and Jim M Wild1

1Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2Department of Bioengeering, Universidad Carlos III de Madrid, Madrid, Spain

Alveolar dimensions change with lung inflation, however, there is currently no consensus on whether this change is primarily due to expansion and if alveolar recruitment plays a role. Here, multiple b-value DW-MRI was used to investigate lung inflation mechanisms in-vivo, and 3D 3He and 129Xe whole lung morphometry (LmD) maps were acquired in five healthy volunteers at lung inflation states of FRC+1L and TLC. Decreases in the anterior to posterior gravitational gradient were observed between FRC+1L and TLC with both nuclei. Smaller than predicted LmD values at TLC suggests that both alveolar expansion and recruitment may occur during lung inflation.

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