Abstract #3316

Analysis of Regional Lung Function Detected by Hyperpolarized Xenon-129 MRI in Subjects with Interstitial Lung Diseases

Kun Qing¹, Talissa A. Altes², John P. Mugler, III¹, Nicholas J. Tustison¹, Kai Ruppert³, Jaime F. Mata¹, Yun Michael Shim¹, G.Wilson Miller¹, Iulian C. Ruset⁴, F.William Hersman^4,5, and Borna Mehrad¹

¹University of Virginia, Charlottesville, VA, United States, ²University of Missouri School of Medicine, Columbia, MO, United States, ³University of Pennsylvania, Philadelphia, PA, United States, ⁴Xemed, LLC, Durham, NH, United States, ⁵University of New Hampshire, Durham, NH, United States

Previous study showed that hyperpolarized xenon-129 MRI is highly sensitive in detecting functional changes in lungs with interstitial lung diseases (ILD). The degree to which these changes vary regionally in the lung has not been determined, however. In this work, we compared abnormalities in lung function in different regions of the lung, and found significant differences in xenon-129 gas uptake between subjects with ILD and controls. These results support that xenon-129 MRI may provide unique information about lung physiology associated with lung fibrosis.

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