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Abstract #3316

Analysis of Regional Lung Function Detected by Hyperpolarized Xenon-129 MRI in Subjects with Interstitial Lung Diseases

Kun Qing1, Talissa A. Altes2, John P. Mugler, III1, Nicholas J. Tustison1, Kai Ruppert3, Jaime F. Mata1, Yun Michael Shim1, G.Wilson Miller1, Iulian C. Ruset4, F.William Hersman4,5, and Borna Mehrad1

1University of Virginia, Charlottesville, VA, United States, 2University of Missouri School of Medicine, Columbia, MO, United States, 3University of Pennsylvania, Philadelphia, PA, United States, 4Xemed, LLC, Durham, NH, United States, 5University of New Hampshire, Durham, NH, United States

Previous study showed that hyperpolarized xenon-129 MRI is highly sensitive in detecting functional changes in lungs with interstitial lung diseases (ILD). The degree to which these changes vary regionally in the lung has not been determined, however. In this work, we compared abnormalities in lung function in different regions of the lung, and found significant differences in xenon-129 gas uptake between subjects with ILD and controls. These results support that xenon-129 MRI may provide unique information about lung physiology associated with lung fibrosis.

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