Abstract #3324

Single Breath CSSR-DWI: A New Method to Simultaneously and Quantitatively Assess the Changes of Respiratory Membrane and Pulmonary Microstructure in Human

Junshuai Xie¹, Huiting Zhang¹, Xiuchao Zhao¹, Haidong Li¹, Sa Xiao¹, Ke Wang², Hao Yang², Xianping Sun¹, Guangyao Wu², Chaohui Ye¹, and Xin Zhou¹

¹Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, People's Republic of China, ²Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China

The blood-gas exchange function and the pulmonary microstructure are generally affected by the lung inflation levels. Here We developed a new method Single Breath CSSR-DWI to simultaneously quantify the respiratory membrane and the pulmonary microstructure via hyperpolarized ¹²⁹Xe in a single breath. A new parameter SVRd/g was defined from ADC and SVRd to characterize the ‘%-predicted dissolved SVR’. Human pulmonary functional and structure information were successfully obtained in a single breath via hyperpolarized ¹²⁹Xe. Compared to the healthy young subjects, SVRd/g of the asymptomatic aged subjects decreases while the size of the pulmonary microstructure increases.

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