Abstract #3325

Quantify Pulmonary Gas-Exchange Function with Hyperpolarized 129Xe CEST MRI

Haidong Li¹, Zhiying Zhang¹, Xiuchao Zhao¹, Yeqing Han¹, Xianping Sun¹, Chaohui Ye¹, and Xin Zhou¹

¹Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, People's Republic of China

In this study, the pulmonary gas-exchange function was quantitatively evaluated globally and regionally by hyperpolarized 129Xe MRI using the method of chemical exchange saturation transfer (CEST). A new parameter, named as pulmonary gas consumption time constant (Toc), was proposed to characterize the gas exchange function. The parameter showed significant difference between the COPD and healthy rats, and we believe it will be a useful parameter in evaluating the pulmonary function.

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