Synopsis: Image registration of lung CT images acquired at different inflation levels has been proposed as a surrogate method to map lung ‘ventilation’. However, this technique requires validation against established ventilation modalities such as hyperpolarised gas MRI. Here, we develop an image acquisition and analysis strategy to facilitate direct spatial correlation of ventilation CT with both hyperpolarised 3He & 129Xe MRI and apply our method to a cohort of lung cancer patients.
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