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Abstract #3326

A spatial comparison of CT-based surrogates of ventilation with hyperpolarized Helium-3 & Xenon-129 MRI

Bilal Tahir1,2, Paul Hughes2, Helen Marshall2, Neil Stewart1, Felix Horn2, Guilhem Collier2, Graham Norquay2, Kerry Hart1, James Swinscoe1, Matthew Hatton1, Jim Wild2, and Rob Ireland1

1Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom, 2Academic Radiology, University of Sheffield, Sheffield, United Kingdom

Synopsis: Image registration of lung CT images acquired at different inflation levels has been proposed as a surrogate method to map lung ‘ventilation’. However, this technique requires validation against established ventilation modalities such as hyperpolarised gas MRI. Here, we develop an image acquisition and analysis strategy to facilitate direct spatial correlation of ventilation CT with both hyperpolarised 3He & 129Xe MRI and apply our method to a cohort of lung cancer patients.

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