The signal dynamics of hyperpolarized 129Xe in the pulmonary capillaries and veins was evaluated by employing multi-TR pulse sequences, with TR values ranging from 100-6000ms. The ratio of signal from 129Xe dissolved in red blood cells (RBC) and tissue/plasma (TP) was found to increase for longer TRs whilst the 129Xe-RBC chemical shift was observed to decrease with increasing TR. This observed chemical shift difference is unprecedented, and understanding the nature of the underlying mechanisms causing this shift is crucial for future in vivo experiments using 129Xe-RBC chemical shift as a measure of blood oxygenation.
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