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Abstract #3328

Assessment of acinar destruction in idiopathic pulmonary fibrosis with hyperpolarised 3He gas diffusion-weighted MRI: reproducibility of ADC metrics and correlation with physiological parameters of disease severity.

Nicholas D Weatherley1, Ho-Fung Chan1, Neil J Stewart1, Laura C Saunders1, Guilhem J Collier1, Graham Norquay1, Madhwesha Rao1, Laurie Smith1, Matthew Austin2, Stephen A Renshaw3, Stephen M Bianchi2, and Jim M Wild1

1Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals, Sheffield, United Kingdom, 3Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

Outcome metrics from diffusion-weighted MRI (DW-MRI) were evaluated for reproducibility and clinical correlation in a cohort of patients with idiopathic pulmonary fibrosis (IPF). It was hypothesized that fibrotic lung tissue in IPF undergoes changes that increase the rate of intra-acinar Brownian diffusion.

Apparent diffusion coefficient (ADC) mean, median and histogram metrics are highly reproducible and correlate both quantitatively with regional fibrosis on CT and qualitatively with carbon monoxide transfer coefficient (KCO) from pulmonary function tests. DW-MRI imaging metrics may provide novel insights into microstructural disease severity in IPF and may prove to be a useful non-ionising imaging biomarker of disease.

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