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Abstract #3329

Hyperpolarized xenon by d-DNP using the clinical GE SpinLab polarizer system

Christian Østergaard Mariager1, Steffen Ringgaard1, Jan Henrik Ardenkjær-Larsen2,3, and Christoffer Laustsen1

1Department of Clinical Medicine, The MR Research Centre, Aarhus University Hospital, Aarhus N, Denmark, 2Department of Electrical Engineering, Center for Hyperpolarization in Magnetic Resonance, Technical University of Denmark, Kgs. Lyngby, Denmark, 3GE Healthcare, Denmark

Hyperpolarized (HP) 129Xe have been demonstrated as a useful probe for magnetic resonance (MR) lung imaging and show promise for in vivo perfusion imaging and brown adipose tissue characterization. Reports of large polarization enhancements for 129Xe using dynamic nuclear polarization (DNP) have raised expectations that DNP can be an alternative to the standard spin exchange optical pumping (SEOP) method. We show that it is possible to produce HP 129Xe gas using the clinical GE SpinLab polarizer, thus extending the practical use of the system beyond the primary purpose of hyperpolarizing liquid biomolecules.

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