Abstract #3329

Hyperpolarized xenon by d-DNP using the clinical GE SpinLab polarizer system

Christian Østergaard Mariager¹, Steffen Ringgaard¹, Jan Henrik Ardenkjær-Larsen^2,3, and Christoffer Laustsen¹

¹Department of Clinical Medicine, The MR Research Centre, Aarhus University Hospital, Aarhus N, Denmark, ²Department of Electrical Engineering, Center for Hyperpolarization in Magnetic Resonance, Technical University of Denmark, Kgs. Lyngby, Denmark, ³GE Healthcare, Denmark

Hyperpolarized (HP) ¹²⁹Xe have been demonstrated as a useful probe for magnetic resonance (MR) lung imaging and show promise for in vivo perfusion imaging and brown adipose tissue characterization. Reports of large polarization enhancements for ¹²⁹Xe using dynamic nuclear polarization (DNP) have raised expectations that DNP can be an alternative to the standard spin exchange optical pumping (SEOP) method. We show that it is possible to produce HP ¹²⁹Xe gas using the clinical GE SpinLab polarizer, thus extending the practical use of the system beyond the primary purpose of hyperpolarizing liquid biomolecules.

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