Abstract #3330

Combination of Variable and Constant Flip Angles for Hyperpolarized 129Xe Multi-b Diffusion MRI in a Single Breath-hold

Weiwei Ruan^1,2, Jianping Zhong¹, Ming Zhang¹, He Deng¹, Yeqing Han¹, Chaohui Ye¹, and Xin Zhou¹

¹Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, People's Republic of China, ²University of Chinese Academy of Sciences, Beijing, People's Republic of China

To propose a novel flip angle scheme for hyperpolarized gas multi-b diffusion MRI. It combined the variable and constant flip angles and was named as the combination of variable and constant flip angle (CVCFA). Computer simulation was used to systematically compare the proposed flip angle scheme with the common-used flip angle schemes, including the interleaved constant flip angle (ICFA) and the variable flip angle (VFA) schemes. The CVCFA scheme was used for hyperpolarized xenon diffusion MRI to measure the pulmonary morphology in rats, noninvasively. The results showed the CVCFA was suited for the hyperpolarized gas multi-b diffusion MRI.

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