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Abstract #3340

Optimal design of motion-compensated diffusion gradient waveforms

Óscar Peña-Nogales1, Rodrigo de Luis-Garcia1, Santiago Aja-Fernández1, Yuxin Zhang2,3, James H. Holmes2, and Diego Hernando2,3

1Laboratorio de Procesado de Imagen, Universidad de Valladolid, Valladolid, Spain, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Diffusion-Weighted MRI (DW-MRI) often suffers from motion-related artifacts in organs that experience physiological motion. Importantly, organ motion during the application of diffusion gradients results in signal losses, which complicate image interpretation and bias quantitative measures. Motion-compensated gradient designs have been proposed, however they typically result in substantially lower b-values or severe concomitant gradient effects. In this work, we develop an approach for design of first- and second-order motion-compensated gradient waveforms based on a b-value maximization formulation including concomitant gradient nulling, and we compare it to existing techniques. The proposed design provides optimized b-values with motion compensation and concomitant gradient nulling.

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