Simultaneous Multi-slice (SMS) techniques excite multiple slices simultaneously to accelerate MRI data acquisition. However, slice separation during image reconstruction is not exact and results in coupling between separated voxels. While this may not be critical for most anatomic imaging methods, small but consistent leakage of information from another slice in a DTI dataset will cause bias in diffusion parameter estimates. Here, we propose a randomized-slice pairing technique to alleviate this problem in diffusion MRI acquisitions.
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