Conventional diffusion MRI acquisitions acquire all slices per volume with the same diffusion weighting. This can have two drawbacks: Excessive heating of gradient hardware caused by multiple repeats of the same combination of large drive currents, and low signal at high b-values, which impairs motion correction based on image registration. For placental diffusion MRI, where large slice stack are needed for spatial coverage and anatomical structure can be lost after diffusion, both of these factors can be extreme. We propose intra-volume interleaving of different diffusion weightings, ordered to facilitate image registration for motion correction and minimise gradient heating.
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