Abstract #3349

To accelerate or not: An Investigation on the Impact of Fast Diffusion Imaging with High Angular Resolution on Diffusion Measures in Fiber Tracts

Chia-Ling Chang¹, Jr-Yuan George Chiou², Ming-Long Wu^1,3,4, Shang-Yueh Tsai⁵, Stephan Ernst Maier^2,6, Bruno Madore², and Tzu-Cheng Chao^1,4

¹Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan, ²Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ³Institute of Applied Computer Science, Harvard University, Cambridge, MA, United States, ⁴Institute of Medical Informatics, National Cheng Kung University, Tainan, Taiwan, ⁵Graduate Institute of Applied Physics, National Cheng Chi University, Taipei, Taiwan, ⁶Department of Radiology, Sahlgrenska Academy, Gothenburg University

A novel technique, Fast Diffusion Imaging with High Angular Resolution, is proposed to achieve whole-brain HARDI scans for clinical applications with better geometrical fidelity and shorter scan time. The present study compares tractography results and diffusion properties of each analyzed fiber tract among four-fold segmented (multi-shot) HARDI scans with different acceleration rates and a clinically used sequence with two-fold SENSE. A fully sampled four-shot HARDI scan was used as the reference. The results suggest that the novel acceleration strategy permits a four-minute scan with fairly compatible results while the clinically used method takes ten minutes.

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