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Abstract #3349

To accelerate or not: An Investigation on the Impact of Fast Diffusion Imaging with High Angular Resolution on Diffusion Measures in Fiber Tracts

Chia-Ling Chang1, Jr-Yuan George Chiou2, Ming-Long Wu1,3,4, Shang-Yueh Tsai5, Stephan Ernst Maier2,6, Bruno Madore2, and Tzu-Cheng Chao1,4

1Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan, 2Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 3Institute of Applied Computer Science, Harvard University, Cambridge, MA, United States, 4Institute of Medical Informatics, National Cheng Kung University, Tainan, Taiwan, 5Graduate Institute of Applied Physics, National Cheng Chi University, Taipei, Taiwan, 6Department of Radiology, Sahlgrenska Academy, Gothenburg University

A novel technique, Fast Diffusion Imaging with High Angular Resolution, is proposed to achieve whole-brain HARDI scans for clinical applications with better geometrical fidelity and shorter scan time. The present study compares tractography results and diffusion properties of each analyzed fiber tract among four-fold segmented (multi-shot) HARDI scans with different acceleration rates and a clinically used sequence with two-fold SENSE. A fully sampled four-shot HARDI scan was used as the reference. The results suggest that the novel acceleration strategy permits a four-minute scan with fairly compatible results while the clinically used method takes ten minutes.

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