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Abstract #3366

Influence of post-processing method on the repeatability of diffusion-weighted imaging parameters in healthy brain

Ashley M Stokes1, Jack T Skinner2, Laura C Bell1, Adrienne N Dula3, Thomas E Yankeelov3, and C. Chad Quarles1

1Translational Bioimaging Group, Barrow Neurological Institute, Phoenix, AZ, United States, 2Imaging Programs, National Comprehensive Cancer Network (NCCN), Philadelphia, PA, United States, 3University of Texas - Austin

The purpose of this study is to investigate the influence of post-processing method on the reproducibility of brain diffusion metrics, including apparent diffusion coefficients (ADCs) and intra-voxel incoherent motion (IVIM) parameters, in healthy controls and to apply these results in a cohort of brain tumor patients undergoing treatment. ADC was highly reproducible for all methods. The IVIM diffusion and perfusion fraction showed the highest reproducibility using constrained fitting, while IVIM pseudo-diffusion showed limited reproducibility. By establishing limits of repeatability for ADC and IVIM metrics, these methods can be applied in neuropathology to determine significant changes related to treatment effects.

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