The purpose of this study is to investigate the influence of post-processing method on the reproducibility of brain diffusion metrics, including apparent diffusion coefficients (ADCs) and intra-voxel incoherent motion (IVIM) parameters, in healthy controls and to apply these results in a cohort of brain tumor patients undergoing treatment. ADC was highly reproducible for all methods. The IVIM diffusion and perfusion fraction showed the highest reproducibility using constrained fitting, while IVIM pseudo-diffusion showed limited reproducibility. By establishing limits of repeatability for ADC and IVIM metrics, these methods can be applied in neuropathology to determine significant changes related to treatment effects.
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