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Abstract #3367

Higher-order statistics of 3D spin displacement probability distributions measured with MAP MRI

Alexandru Vlad Avram1, Elizabeth Hutchinson2, and Peter Basser2

1NIBIB, National Institutes of Health, Bethesda, MD, United States, 2NICHD, National Institutes of Health, Bethesda, MD, United States

We compute the higher-order statistics of the 3D spin displacement probability distributions measured with mean apparent propagator (MAP) MRI and quantify microstructural tissue parameters such as the mean kurtosis (MK), axial kurtosis (K), radial kurtosis (K) and kurtosis fractional anisotropy (FAK). This extension of the family of MAP tissue parameters provides a direct link between the frameworks of MAP MRI and other advanced diffusion techniques facilitating interpretation of findings in clinical MAP MRI studies in the context of existing literature on advanced diffusion MRI applications.

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