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Abstract #3371

Diffusion - Tensor Based Morphometry (DTBM) of Normal Human Brain Development from Infancy to Adulthood

Amritha Nayak1,2,3, Neda Sadeghi2, M Okan Irfanoglu1,2,3, and Carlo Pierpaoli1,2

1Quantitative Medical Imaging Section, National Institute of Biomedical imaging and Bioengineering, Bethesda, MD, United States, 2Section for Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States, 3Henry . M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States

During postnatal brain development brain structures undergo large changes in size, shape, composition and microstructural appearance. Diffusion tensor imaging (DTI) is an MRI modality particularly informative on white matter. We perform tensor based morphometry (TBM) using deformation fields constructed using all scalar and directional information provided by diffusion tensor data (DTBM) to measure volumetric changes of brain structures from neonate to adulthood. Our results indicate that DTBM reveals interesting patterns in the developmental trajectories for different structures in the human brain. This information would be important to characterize deviation from normal developmental patterns due to developmental delay or other disorders.

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