A well-known dilemma in DW-MRI acquisitions is to determine the extent to which signal-to-noise ratio (SNR) can be can be sacrificed in favour of higher spatial resolution on one hand, and in favour of shorter acquisition time on the other. In this study we quantify the reproducibility of spherical deconvolution results at 3 spatial resolutions with and without denoising, as it is still unclear how denoising methods6 affect the uncertainty in subsequent diffusion model fitting and whether it introduces or improves bias in modelled fibre direction.
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