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Abstract #3384

Oscillating gradient improves the sensitivity of diffusion functional MRI

Dan Wu1, Hanbing Lu2, Yihong Yang2, and Jiangyang Zhang3

1Radiology, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, 2Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, United States, 3Radiology, New York University School of Medicine, NY, United States

Synopsis: Diffusion functional MRI (DfMRI) has been proposed to detect neuronal activations more directly than BOLD-fMRI, but its sensitivity to cell swelling associated with neuronal activities remains less known. Numerical simulations suggest that oscillating gradient spin echo (OGSE) diffusion MRI is more sensitive to changes in cell size than conventional pulsed gradient spin echo (PGSE) diffusion MRI. In adult rat brain DfMRI experiments with forepaw stimulation, ADC measured by OGSE showed significant reductions during stimulation, and the reductions were significantly larger than those measured by PGSE, suggesting OGSE may be more sensitive to cell swelling associated with neuronal activation than PGSE.

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