Double diffusion encoding experiments with two weighting periods applied successively offer access to microscopic tissue properties and can provide information complementary to diffusion tensor imaging. The MA index derived from such measurements with long mixing times, depends on the cell eccentricities, i.e. the microscopic diffusion anisotropy, and can be determined in the human brain. However, its derivation is based on ideal timing parameters, infinitely short gradient pulses and long diffusion and mixing times that cannot be gained in practice. In this study, the effect of realistic timing parameters on the MA of restricted diffusion is investigated with Monte Carlo simulations.
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