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Abstract #3386

Quantification of pore size distributions using double diffusion encoding: assessment of the feasibility on a clinical system

Gaetan Duchene1, Frank Peeters1, Jorge Abarca-Quinones1, and Thierry Duprez1

1Medical imaging dept, St-Luc University hospital, Université Catholique de Louvain, Brussels, Belgium

Recently, Double Diffusion Encoding (DDE) has been proposed for quantification of pore size distributions in a voxel or a Region Of Interest. Although the technique has been validated on animals with experimental MR systems, its translation to human scanners is challenging, mainly because of the limited gradient strength available on clinical systems. In this work, we present a validation of DDE on a clinical scanner on a biological phantom (asparagus). Furthermore, we restricted the acquisition time to 16 minutes which remains acceptable in clinical conditions.

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