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Abstract #3387

In-vivo Bundle-Specific Axon Diameter Distributions Estimation across the Corpus Callosum

Muhamed Barakovic1, David Romascano1, Gabriel Girard1, Maxime Descoteaux1,2, Jean-Philippe Thiran1,3, and Alessandro Daducci1,3,4

1Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Sheerbrooke Connectivity Imaging Laboratory (SCIL), University of Sheerbrooke, Canada, 3University Hospital Center (CHUV) and University of Lausanne (UNIL), Switzerland, 4Department of Computer Science, University of Verona, Italy

Over the last decade microstructure imaging has become commonly endorsed to estimate quantitative features of neuronal tissue. However, those techniques estimate the microstructure only locally. Microstructure informed tractography was recently proposed to bolster microstructure estimates by accounting for the structure of the white matter bundles. The purpose of this study was to extend this novel technique for evaluating bundle-specific axon diameter distributions and investigate bundle-specific properties in the human brain. The experiment was performed on the MGH adult HCP dataset. The findings suggest potential application in the estimation of the axon diameter distribution along white matter bundles in whole-brain tractograms.

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