Abstract #3394

Quantifying microstructure in low and high-grade brain tumours using VERDICT MRI

Thomas A Roberts¹, Harpreet Hyare^2,3, Ben Hipwell¹, Andrada Ianus⁴, James O Breen-Norris¹, Eleftheria Panagiotaki⁴, David Atkinson², Shonit Punwani², Jeremy Rees⁵, Sebastian Brandner⁶, Daniel C Alexander⁴, and Simon Walker-Samuel¹

¹Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ²Centre for Medical Imaging, Division of Medicine, University College London, London, United Kingdom, ³UCL Institute of Neurology, Department of Brain Repair and Rehabilitation, London, United Kingdom, ⁴Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ⁵National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁶Division of Neuropathology, Institute of Neurology, University College London, United Kingdom

VERDICT (Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours) MRI is a diffusion imaging technique which has shown promise in revealing information about tumour microstructure beyond ADC measures and structural imaging. We report the first application of VERDICT to human brain tumours. In this feasibility study, we characterise a mixed group of brain tumours using VERDICT, which includes a range of both low and high-grade gliomas; compare the VERDICT parameter maps with ADC maps, post-contrast T1w images and histological grading; and examine the repeatability of the technique.

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