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Abstract #3394

Quantifying microstructure in low and high-grade brain tumours using VERDICT MRI

Thomas A Roberts1, Harpreet Hyare2,3, Ben Hipwell1, Andrada Ianus4, James O Breen-Norris1, Eleftheria Panagiotaki4, David Atkinson2, Shonit Punwani2, Jeremy Rees5, Sebastian Brandner6, Daniel C Alexander4, and Simon Walker-Samuel1

1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2Centre for Medical Imaging, Division of Medicine, University College London, London, United Kingdom, 3UCL Institute of Neurology, Department of Brain Repair and Rehabilitation, London, United Kingdom, 4Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 5National Hospital for Neurology and Neurosurgery, London, United Kingdom, 6Division of Neuropathology, Institute of Neurology, University College London, United Kingdom

VERDICT (Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours) MRI is a diffusion imaging technique which has shown promise in revealing information about tumour microstructure beyond ADC measures and structural imaging. We report the first application of VERDICT to human brain tumours. In this feasibility study, we characterise a mixed group of brain tumours using VERDICT, which includes a range of both low and high-grade gliomas; compare the VERDICT parameter maps with ADC maps, post-contrast T1w images and histological grading; and examine the repeatability of the technique.

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