Abstract #3395

Rat brain development assessed by high-field neurite orientation dispersion and density imaging

Nicolas Kunz¹, Stéphane V Sizonenko², Rolf Gruetter^1,3, Petra S Hüppi², and Yohan van de Looij^1,2

¹Laboratoire d'imagerie fonctionnelle et métabolique, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Département développement et croissance, Université de Genève, Geneva, Switzerland, ³Département de radiologie, Geneva and Lausanne, Switzerland

Diffusion tensor imaging (DTI) has been widely used to study rodent brain development. Nevertheless, the parameters derived from DTI are sensitive to, but non-specific to, the tissue’s microstructure. Recently, NODDI (neurite orientation dispersion and density imaging) has been proposed. We aimed to estimate the real input of NODDI derived parameters in rodent brain development. ODI appears more accurate and specific to reflect GM (increase with dendritic arborization) and WM (decrease with myelination) development than FA and could be a very important parameter in the assessment of perinatal brain injuries. Conclusion about the other NODDI estimates requires further experiments.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.