Meeting Banner
Abstract #3396

Disentangling myelination and axonal density using NODDI and mcDESPOT – a multimodal microstructure imaging approach

Samira Bouyagoub1, Nicholas G. Dowell1, Charlotte L. Clarke1, Tobias C. Wood2,3, Hui Zhang4, and Mara Cercignani1

1Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, 2Neuroimaging, IoPPN, King’s College London, London, United Kingdom, 3Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer’s Disease, London, United Kingdom, 4Centre for Medical Image Computing, University College London, London, United Kingdom

There is an increasing demand for specific tissue microstructure markers that can be related to demyelination and axonal loss. Quantitative MRI techniques are sensitive to microscopic changes but tend to be non-specific. We propose to combine NODDI, a popular MRI diffusion technique, with mcDESPOT, a multi-component relaxation analysis technique, to obtain separate estimates of the volumes of myelin, extra-cellular and intra-cellular spaces. This multimodal MR approach opens the possibility to disentangle changes to myelination and axonal density with the exciting prospect of achieving in vivo histology.

This abstract and the presentation materials are available to members only; a login is required.

Join Here