Abstract #3398

Detection of distinct tract-specific axon diameter and density estimates in the in vivo human brain using TractCaliber MRI

Susie Y Huang¹, Thomas Witzel¹, Qiuyun Fan¹, Barbara Wichtmann², Aapo Nummenmaa¹, Lawrence L Wald¹, and Eric Klawiter³

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ²Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ³Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

In this work, we apply the TractCaliber approach to a group of healthy subjects and show that distinct tract-specific estimates of axon diameter may be obtained in different white matter tracts in the normal human brain. Larger diameter axons are consistently estimated in the corticospinal tracts and are shown to be distinct from those in the cingulum, an adjacent and orthogonal white matter tract. The development of robust tract-specific axon diameter-weighted maps may be useful for refining existing tractography algorithms.

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