Multimodal imaging is very promising for characterising brain microstructure in vivo, but it is usually performed employing a variety of signal readouts, which disrupts the spatial correspondence of the multimodal features. Here we demonstrate a multimodal imaging protocol for detailed characterisation of brain microstructure with unified single-shot EPI readout. Our aim is to provide macromolecular volume via inversion recovery spin echo, neurite morphology via diffusion imaging in close spatial alignment and thus to combine those for estimating myelin g-ratio. We show that our protocol enables the evaluation of parametric maps with high reproducibility that capture biological differences among healthy subjects.
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