Abstract #3400

Probing Microstructure of Brain Tumor: A NODDI Study

Shin Tai Chong¹, Hung-Wen Kao², Chien-Yuan Eddy Lin^3,4, Chiao-Chi Chen⁵, Ching-Po Lin¹, and Chen Chang⁵

¹Institute of Neuroscience, National Yang-Ming University, Taipei city, Taiwan, ²Department of radiology, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ³GE Healthcare, Taipei, Taiwan, ⁴GE Healthcare MR Research China, Beijing, People's Republic of China, ⁵Institute of Biomedical Sciences, Academia Sinica, Taiwan

We hypothesized that the model-based diffusion model, Neurite Orientation Dispersion and Density Imaging (NODDI), could help probing microstructures of brain tumos in different types and gradings. The model perfomed better than a conventional diffusion model in differetiating meningiomas and gliomas in different grades while the two models showed significant differences of the diffusion indices between meningiomas and gliomas. In the NODDI analysis, both VF_ic and VF_ec show great potential to probe the cellularity of brain tumors.

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