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Abstract #3403

Diffusion-Weighted Split-Echo RARE Imaging Free Of Geometric Distortion for Renal MRI at Ultrahigh Fields

Joao Periquito1, Katharina Paul1, Till Huelnhagen1, Yiyi Ji1, Min-Chi Ku1, Kathleen Cantow2, Erdmann Seeliger2, Bert Flemming2, Dirk Grosenick3, Andreas Pohlmann1, and Thoralf Niendorf1,4

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Institut für Vegetative Physiologie, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Physikalisch-Tecnische Bundesanstalt (PTB), Berlin, Germany, 4Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

T2* mapping does not fully represent renal tissue oxygenation. Diffusion-weighted imaging (DWI) can provide information about confounding factors, which can be used to correct T2*. The most widely used DWI technique SE-EPI is sensitive to magnetic field inhomogeneities and hence prone to geometric distortions. In this work we propose a diffusion-weighted Rapid Acquisition Refocusing Enhancement (RARE) variant for DWI of the rat kidney free of geometric distortions. Phantom experiments validated the diffusion weighting implementation in the common RARE sequence. Ex-vivo and in-vivo experiments using diffusion-weighted RARE showed no geometric distortions at 9.4 Tesla.

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