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Abstract #3405

Application of diffusion kurtosis MR imaging in characterization of renal cell carcinomas with different pathological types and grades

Jie Zhu1, Ying Sa Li1, Jie Xiao Luo1, Dan Dan Zheng2, and Min Chen1

1Beijing Hospital, Beijing, People's Republic of China, 2GE healthcare, MR research China, People's Republic of China

Identification of subtypes and pathological grades of renal cell carcinoma (RCC) prior to treatment has clinical significance in determining a treatment strategy and evaluating prognosis. In our research, we detected microstructural differences of RCC by using diffusion kurtosis imaging (DKI). The results showed that DKI had good inter- and intra-observer reproducibility of RCC as a new reliable noninvasive biomarker. Kurtosis metrics showed statistical differences between RCC and contralateral renal parenchyma, among the subtypes of RCC, and between low- and high- grade clear cell RCCs. Thus, DKI has the potential application in depicting the microstructural characteristics of RCC.

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