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Abstract #3409

Optimization of Intravoxel Incoherent Motion Measurement in Diffusion-Weighted Imaging of Breast Cancer

Wengjing Chen1, Juan Zhang2, Dan Long2, Zhenchang Wang3, and Jianming Zhu1

1Biomedical Engineering, China Jiliang University, Hangzhou, People's Republic of China, 2Radiology, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China, 3Radiology, Beijing Friendship Hospital, Beijing, People's Republic of China

The purpose was to use intra-voxel incoherent motion (IVIM) measurement in DWI to distinguish benign from malignant breast tissues. IVIM-derived parameter maps D, f, and D* were computed using segmented fitting method with proper threshold b-value. The region of interests were avoided the area of calcification. With pathological diagnosis as the gold standard, receiver operating characteristic (ROC) curves for three parameters and f × D* reflect that the area under the curve (AUC) of D and f × D* are 0.862 and 0.726, respectively. It suggested that these two parameters have high significance for the diagnosis of breast cancer lesions.

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