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Abstract #3410

Diffusion weighted MR imaging–derived histogram Metrics for quantitative assessment of response to neoadjuvant chemoradiotherapy in local advanced rectal cancer: Initial Experience and Comparison between Single-Section and Volumetric Analyses

Yanfen Cui1, Xiaotang Yang 1, and Yong Zhang2

1Shanxi Province Tumor Hospital, Taiyuan, People's Republic of China, 2MR Advanced Application and Research Center, GE Healthcare China, People's Republic of China

This retrospective study was to determine the diagnostic accuracy of apparent diffusion coefficient (ADC) values to assess the response to CRT in patient with local advanced rectal cancer by using histogram analysis derived from single-section (SS) and whole-tumor volume (WTV) regions of interest (ROIs). and found that Post-CRT ADC histogram metrics yield greater accuracy in discrimination between good and poor responders, especially in improving the specificity, compared with the mean ADC values.

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