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Abstract #3417

Detection of peripheral zone prostate cancer using diffusion-weighted intravoxel incoherent motion imaging

Jin Shang1, Hui Zhang1, Miaoling Li1, Jian Yang1, and Rong Wang*1

1Department of radiology, the first affiliated hospital of medical college, Xi'an Jiaotong University, Xi'an, People's Republic of China

DWI has been proven to improve prostate cancer detection, and it reflects and measures the diffusion of water molecules within biological tissues due to thermal Brownian motion. However, to improve the significance of DWI, it is necessary to evaluate separately the two components of diffusion: the puremolecular diffusion and the perfusion-related diffusion originating from capillary microcirculation. IVIM-DWI, applying a bi-exponential fitting function, allows the extraction of pure molecular diffusion parameters (D) and perfusion-related diffusion parameters (D* and f). Therefore, the aim of this study is to further characterize and compare the biexponential nature of the diffusion related signal decay with multiple b-factors for PZ PCa and healthy PZ areas.

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