DWI has been proven to improve prostate cancer detection, and it reflects and measures the diffusion of water molecules within biological tissues due to thermal Brownian motion. However, to improve the significance of DWI, it is necessary to evaluate separately the two components of diffusion: the puremolecular diffusion and the perfusion-related diffusion originating from capillary microcirculation. IVIM-DWI, applying a bi-exponential fitting function, allows the extraction of pure molecular diffusion parameters (D) and perfusion-related diffusion parameters (D* and f). Therefore, the aim of this study is to further characterize and compare the biexponential nature of the diffusion related signal decay with multiple b-factors for PZ PCa and healthy PZ areas.
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