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Abstract #3422

Use of texture analysis of intravoxel incoherent motion (IVIM) in evaluating the expression of Ki67 of hepatitis B virus-related hepatocellular carcinoma (HCC)

Qungang Shan1, Jingbiao Chen1, Ronghua Yan1, Yao Zhang1, Hao Yang1, Xin Li2, Zhongping Zhang3, Yunhong Shu4, Churong Lin, Tianhui Zhang1, Bingjun He1, Zhuang Kang1, Xi Long1, and Jin Wang1

1Department of Radiology, the Third Affiliated Hospital, Sun Yat-sen University (SYSU), Guangzhou, People's Republic of China, 2GE Healthcare MR Research China, Guangzhou, People's Republic of China, 3MR Research China,GE Healthcare, Beijing, 4Mayo Clinic

HCC is the second cause of cancer-related deaths and most HCC patients are accompanied with hepatitis B virus-related cirrhosis in China. Ki67 is a protein reflecting the proliferative activity of HCC and could be used as a predictor of prognosis. We assessed the value of the texture parameters in evaluating the expression of Ki67of HBV-related HCCs by whole tumor analysis. Our results showed that Dclusterprominence showed best diagnostic performance among all texture parameters. ADC and IVIM derived texture parameters might be used as useful and noninvasive biomarkers for evaluating the expression of Ki67 of HBV-related HCCs.

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