HCC is the second cause of cancer-related deaths and most HCC patients are accompanied with hepatitis B virus-related cirrhosis in China. Ki67 is a protein reflecting the proliferative activity of HCC and could be used as a predictor of prognosis. We assessed the value of the texture parameters in evaluating the expression of Ki67of HBV-related HCCs by whole tumor analysis. Our results showed that Dclusterprominence showed best diagnostic performance among all texture parameters. ADC and IVIM derived texture parameters might be used as useful and noninvasive biomarkers for evaluating the expression of Ki67 of HBV-related HCCs.