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Abstract #3423

Feasibility of diffusion kurtosis imaging as a tool for differentiation between benign and malignant uterine lesions

Yoshihiko Fukukura1, Yuichi Kumagae1, Masanoari Nakajo1, Kiyohisa Kamimura1, Aya Umanodan1, Takashi Iwanaga2, Tomoyuki Okuaki3, and Takashi Yoshiura1

1Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, 2Radiological Technology, Kagoshima University Hospital, Kagoshima, Japan, 3Philips Electronics Japan, TN, Japan

This study focused on the feasibility of DKI for differentiating benign from malignant uterine lesions. The ADC and D of malignant tumor (MT) were significantly lower than those of endometrial hyperplasia (EH) (p=0.005 and 0.004), uterine fibroid (UF) (both, p<0.001), normal endometrium (NE) (both, p<0.001), and normal myometrium (NM) (both, p<0.001), which indicative of the increased cellularity within uterine malignant tumor that resulted in restricted water diffusion. K was significantly higher in MT than in EH (p=0.003), UF (p<0.001), NE (p<0.001), and NM (p<0.001), possibly representing complexity of tissue microstructure in MT compared to benign lesions. DKI enables differentiate benign from malignant uterine lesions.

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