Abstract #3428

Inter-ethnic variation and SCD1 polymorphism predict risk for intramyocellular lipid accumulation in early childhood

Navin Michael¹, Varsha Gupta¹, Suresh Anand Sadananthan¹, Aparna Sampathkumar¹, Li Chen¹, Hong Pan¹, Mya Thway Tint², Kuan Jin Lee³, Lynette Pei-Chi Shek⁴, Yap Kok Peng Fabian^5,6, Keith M Godfrey⁷, Melvin Khee-Shing Leow^8,9, Yung Seng Lee^1,4, Michael S Kramer^2,10,11, Yap Seng Chong^1,2, Christiani Jeyakumar Henry⁸, Marielle Valerie Fortier¹², Peter D Gluckman^1,13, Neerja Karnani^1,14, and S. Sendhil Velan³

¹Singapore Institute for Clinical Sciences, A*STAR, Singapore, ²Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, ³Singapore BioImaging Consortium, A*STAR, Singapore, ⁴Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, ⁵Department of Paediatric Endocrinology, KK Women’s and Children’s Hospital, Singapore, ⁶Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, ⁷MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, ⁸Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, A*STAR, Singapore, ⁹Department of Endocrinology, Tan Tock Seng Hospital, Singapore, ¹⁰Department of Paediatrics, Faculty of Medicine, McGill University, Montreal, Canada, ¹¹Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Canada, ¹²Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore, ¹³Liggins Institute, University of Auckland, Auckland, New Zealand, ¹⁴Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

A large intramyocellular lipid (IMCL) pool is associated with early pathogenesis of insulin resistance and type 2 diabetes. Studies from mother-offspring cohorts indicate that, like obesity and metabolic traits, IMCL is also highly heritable. However, here have been not many studies on the effect of genetic variation on IMCL. Although a number of genome-wide association studies (GWAS) have established associations between several genetic loci and metabolic disorders, it is not yet known if these loci also contribute to IMCL levels, and help explain ethnic difference in IMCL levels. In this study, we examined the ethnic differences (Indian, Malay and Chinese) in IMCL in Singaporean children and the genetic risk variant(s) associated with these differences.

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