Abstract #3435

Urine Metabolic profiling of patients with colorectal cancer based on NMR and Pattern Recognition

Wang Zhening¹, Liang Jiahao¹, Huang Yao¹, Ma Changchun², Wu Renhua¹, Yang Jurong³, Liu Xingmu⁴, and Lin Yan¹

¹Radiology Department, Second Affiliated Hospital, Shantou University Medical College, Shantou, People's Republic of China, ²Radiation Oncology, Affiliated Tumor Hospital, Shantou University Medical College, Shantou, People's Republic of China, ³Shantou University Central Laboratory and NMR Unit, Shantou, People's Republic of China, ⁴Surgery Deparment, Second Affiliated Hospital, Shantou University Medical College, Shantou, People's Republic of China

After our fecal metabonomic study of colorectal cancer (CRC) patients recently published in Oncotarget , we profiled urine metabolites from the same group of CRC patients, 40 age-matched healthy controls (HC), 18 esophageal cancers (EC), using proton nuclear magnetic resonance spectroscopy in conjunction with a multivariate statistics technique. OPLS-DA revealed that each stage of CRC could be clearly distinguished from HC and EC based on their different metabolomic profiles. These altered urine metabolites of CRC patients from HC potentially involved in the disrupted common pathways, and the different metabolites in CRC compare to EC indicated the special of the CRC.

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