Lower fat content within brown adipose tissue (BAT) compared to white adipose tissue (WAT) has been exploited using Dixon-based MRI imaging methods to visualize BAT but is subject to inter-rater variability. To determine the optimal fat fraction threshold for identifying BAT, receiver operating characteristic (ROC) analyses of fat fraction maps derived from 3 point IDEAL MRI scans were performed for sixteen subjects.
This method had good-to-excellent accuracy in four cases, and fair accuracy in two, but failed in ten. A single universal cut-off point to differentiate BAT and WAT could not be identified, instead the optimal thresholds varied between individuals.
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