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Abstract #3440

Metabolic Imaging of Brown Adipose Tissue Activation by Exercise in Control and High Fat Diet Fed Rats

Venkatesh Gopalan1, Jadegoud Yaligar1, Sanjay Kumar Verma1, Suresh Anand Sadananthan2, Anna Ulyanova1, Navin Michael2, Anantharaj Rengaraj1, Tian Xianfeng1, and S. Sendhil Velan1,2

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 2Singapore Institute for Clinical Sciences, Singapore, Singapore

Exercise is an important intervention for correction of irregular fat-partitioning and treatment of metabolic dysfunction. There is a large interest in development of non-invasive methods for activation of brown adipose tissue (BAT) due to its potential to combat obesity. In this study we have investigated exercise induced BAT activation and IMCL from skeletal muscle of rodents fed with control and high fat diet. Our results show that exercise modulates the brown fat with reduction in fat fraction, increased UCP1 expression and reduction in “white” like adipocytes in control and high fat diet fed rats.

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