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Abstract #3454

Providing Ground Truth Quantification of Anisotropic Diffusion MRI Imaging with a Hollow Textile Phantom

Sudhir Kumar Pathak1, Catherine Fissell1, David Okonkwo2, and Walter Schneider1

1Psychology, University Of Pittsburgh, Pittsburgh, PA, United States, 2Neurosurgery, University Of Pittsburgh Medical Center, PA, United States

A novel Textile Anisotropic Brain Imaging Phantom incorporating textile hollow fibers (taxons with inner/outer diameter 12/34 micron) is used to validate diffusion MRI imaging (dMRI). The taxon intra and extra spaces can be filled with water or deuterium. A taxon crossing pattern and a packing density pattern is manufactured to test orientation and the amount of taxons. NODDI based Intra-cellular volume fraction is correlated with the amount of taxons (r2=0.96) as compared to FA which is poor predictor with r2=0.11. Fiber crossings are estimated using Constrained Spherical Deconvolution techniques and can be resolved for angles greater then 45 degrees.

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