This work investigates the stability of a water-based biomimetic tumour tissue phantom, and evaluates its potential as a tool for validating diffusion-weighted (DW) MRI measurements. As with biological tissue, and unlike most previous phantoms for tumour DW-MRI, the phantom’s apparent diffusion coefficient depends on diffusion time, with values stable over six months. DW-MRI-based estimates of microstructural parameters exhibited bias, possibly indicating limitations in the analysis model or acquisition scheme. It is envisaged that such phantoms will aid investigation of DW-MRI tumour microstructural models, and more generally will act as realistic test objects for comparing DW-MRI-derived biomarkers obtained from different scanners/sites.
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