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Abstract #3453

A biomimetic tumour tissue phantom for validating diffusion-weighted MRI measurements

Damien J. McHugh1,2, Fenglei Zhou1,2,3, Penny L. Hubbard Cristinacce1, Josephine H. Naish1, and Geoffrey J. M. Parker1,2,4

1Centre for Imaging Sciences, The University of Manchester, Manchester, United Kingdom, 2CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, Manchester, United Kingdom, 3The School of Materials, The University of Manchester, Manchester, United Kingdom, 4Bioxydyn Ltd., Manchester, United Kingdom

This work investigates the stability of a water-based biomimetic tumour tissue phantom, and evaluates its potential as a tool for validating diffusion-weighted (DW) MRI measurements. As with biological tissue, and unlike most previous phantoms for tumour DW-MRI, the phantom’s apparent diffusion coefficient depends on diffusion time, with values stable over six months. DW-MRI-based estimates of microstructural parameters exhibited bias, possibly indicating limitations in the analysis model or acquisition scheme. It is envisaged that such phantoms will aid investigation of DW-MRI tumour microstructural models, and more generally will act as realistic test objects for comparing DW-MRI-derived biomarkers obtained from different scanners/sites.

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