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Abstract #3466

Reduction of susceptibility-induced field gradients in multi-fibre diffusion phantoms via susceptibility matching

Ezequiel Farrher1, Johannes Lindemeyer1, Farida Grinberg1,2, Ana-Maria Oros-Peusquens1, and N. Jon Shah1,2,3

1Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich, Jülich, Germany, 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 3JARA – BRAIN – Translational Medicine, RWTH Aachen University, Aachen, Germany

Studies performing diffusion-weighted MRI on anisotropic fibre phantoms suffer from microscopic background field gradients induced by differences in the magnetic susceptibility of the employed materials. We present a particularly promising approach that makes use of a matched magnesium chloride solution to eliminate these effects. The method is thoroughly studied and successfully validated on a crossing-fibre phantom containing two perpendicularly crossing fibre populations. The obtained results are no longer subject to any orientation-dependence with respect to B0.

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