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Abstract #3467

Diffusion radiomics analysis in intratumoral heterogeneity of murine prostate cancer following radiotherapy: pixel-wise correlation with histology

Yu-Chun Lin1,2, Gigin Lin1,2, and Chun-Chieh Wang2,3

1Dep. Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 2Chang Gung University, Taoyuan, Taiwan, 3Dep. Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

To investigate the biological meaning of apparent diffusion coefficient (ADC) in tumors following radiotherapy. Five mice bearing TRAMP-C1 tumor were half-irradiated. Diffusion-weighted images were acquired using multiple b-values of up 0 to 3000 s/mm2. The pixelwise ADC positively correlated with extracellular space and nuclear size, and negatively correlated with nuclear count, cytoplasmic space and nuclear space. Optimal ADC was achieved at b-value of 800 s/mm2 in determining the treatment response. Pixelwise ADC values correlate with histology metrics might be a means of in vivo radiomics biomarkers for evaluating tumor heterogeneity and responses to radiotherapy.

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