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Abstract #3468

Hypoxia imaging of head and neck carcinoma: Correlation between DWI parameters and FAZA-PET activity

Akiko Imaizumi1,2, Takayuki Obata1, Yasuhiko Tachibana1, Masayuki Inubushi3, Mitsuru Koizumi4, Kyosan Yoshikawa5, Ming-Rong Zhang6, Katsuyuki Tanimoto7, Rintaro Harada8, Takashi Uno8, and Tsuneo Saga9

1Applied MRI Research, Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 2Department of Oral and Maxillofacial Radiology, Tokyo Dental College, Tokyo, Japan, 3Department of Nuclear Medicine, Kawasaki Medical School, 4Department of Nuclear Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 5Molecular Imaging and Theranostics, National Institute of Radiological Sciences, 6Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, 7National Institute of Radiological Sciences Hospital, 8Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, 9Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University

To investigate the usefulness of diffusion-weighted imaging (DWI) for visualizing hypoxia of head and neck carcinoma, the correlation between DWI parameter estimates and 18F-fluoroazomycin arabinoside (FAZA) positron emission tomography (PET) activity was evaluated. The diffusion coefficients and fractions of the fast and slow compartments according to the 2-compartment model (Dfast, Dslow and Ffast, Fslow) were estimated. The diffusional kurtosis (K) and the corrected diffusion coefficient (D) were also obtained according to the diffusional kurtosis imaging (DKI) method. Amongst the DWI estimates, Dslow and K were significantly correlated with FAZA-PET activity, which suggests they might be useful as indicators of hypoxia.

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