Abstract #3468

Hypoxia imaging of head and neck carcinoma: Correlation between DWI parameters and FAZA-PET activity

Akiko Imaizumi^1,2, Takayuki Obata¹, Yasuhiko Tachibana¹, Masayuki Inubushi³, Mitsuru Koizumi⁴, Kyosan Yoshikawa⁵, Ming-Rong Zhang⁶, Katsuyuki Tanimoto⁷, Rintaro Harada⁸, Takashi Uno⁸, and Tsuneo Saga⁹

¹Applied MRI Research, Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ²Department of Oral and Maxillofacial Radiology, Tokyo Dental College, Tokyo, Japan, ³Department of Nuclear Medicine, Kawasaki Medical School, ⁴Department of Nuclear Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research, ⁵Molecular Imaging and Theranostics, National Institute of Radiological Sciences, ⁶Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, ⁷National Institute of Radiological Sciences Hospital, ⁸Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, ⁹Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University

To investigate the usefulness of diffusion-weighted imaging (DWI) for visualizing hypoxia of head and neck carcinoma, the correlation between DWI parameter estimates and ¹⁸F-fluoroazomycin arabinoside (FAZA) positron emission tomography (PET) activity was evaluated. The diffusion coefficients and fractions of the fast and slow compartments according to the 2-compartment model (D_fast, D_slow and F_fast, F_slow) were estimated. The diffusional kurtosis (K) and the corrected diffusion coefficient (D) were also obtained according to the diffusional kurtosis imaging (DKI) method. Amongst the DWI estimates, D_slow and K were significantly correlated with FAZA-PET activity, which suggests they might be useful as indicators of hypoxia.

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