Abstract #3469

7.0 T Diffusion Tensor Imaging Evaluation of Rabbit Sciatic Nerve Microstructure with Histologic Correlation

Tina Jeon¹, Emil Stefan Vutescu², Eric Aronowitz³, Henning U Voss³, Jonathan P Dyke³, and Darryl B Sneag¹

¹Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, ²3Department of Hand and Upper Extremity Service, Hospital for Special Surgery, New York, NY, United States, ³Citigroup Biomedical Imaging Center, Weill Cornell Medical College, New York, NY

High-resolution DTI is a promising tool to evaluate peripheral nerve regeneration following surgical repair of nerve injury. The spatial resolution achieved with 7.0 T allowed us to more confidently interrogate the nerve for measuring fractional anisotropy (FA) and diffusivity and to perform fiber tracking as compared to 3.0 T. Among DTI metrics, FA correlated the greatest with axonal density and diameter. These findings support that DTI has the potential to measure axonal regeneration in the peripheral nerves at preclinical and clinical field strengths.

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