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Abstract #3470

Diffusion-weighted MRI of node tissue: correlation of mean diffusivities and cellularity.

Mariaulpa Sahalan1, Aritrick Chatterjee1, Nyoman Kurniawan2, Gary Cowin2, Laurence Gluch3, Carl Power4, Geoffrey Watson5, Kevin Tay6, Julie Fletcher7, David Taylor8, and Roger Bourne1

1Faculty of Health Sciences, The University of Sydney, NSW, Australia, 2Centre for Advanced Imaging, University of Queensland, Brisbane, Australia, 3The Strathfield Breast Centre, NSW, Australia, 4Biological Resources Imaging Laboratory, University of New South Wales, NSW, Australia, 5Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, NSW, Australia, 6Westmead Breast Cancer Institute, NSW, Australia, 7Concord Repatriation General Hospital, NSW, Australia, 8Vetnostics, NSW, Australia

Improvement of sensitivity and specificity in DWI-based assessment of nodal diseases is dependent on a better understanding of how nodal microstructures affect the water diffusivity in tissue. In this abstract we report the first diffusion microimaging investigation of formalin fixed node tissue with the aim of assessing any correlation between mean diffusivity and cellularity. Mean diffusivity was calculated in ROI corresponding to distinct node sub-structures. Nuclei were segmented semi-automatically to measure the cellularity metrics: nuclear count and nuclear area. The results showed there is no significant correlation between mean diffusivity with cellularity metrics in the nodal tissues.

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