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Abstract #3473

Reducing complexity of functional imaging: free-breathing imaging based ADC and IVIM measurements are as accurate as breath-hold measurements in renal cell carcinoma

Neil P Jerome1,2, Matthew R Orton2, James A d'Arcy2, David J Collins2, Martin O Leach2, and Dow-Mu Koh3

1Department of Circulation and Medical Imaging, NTNU - Norwegian University of Science and Technology, Trondheim, Norway, 2Radiotherapy & Imaging, The Institute of Cancer Research, London, United Kingdom, 3Department of Radiology, The Royal Marsden Hospital, London, United Kingdom

Respiratory motion represents a serious confounding factor for abdominal imaging; for more complex diffusion models such as IVIM, acquisition of diffusion-weighted images in successive breath-holds offers control of motion for sharper images. In this patient study, DWI was performed in free-breathing and consecutive breath-holds, without registration, on successive days without intervention to determine repeatability. Derived tumour ROI parameters from ADC and IVIM models were not significantly affected between breathing regimes, but observed coefficients of variation for free-breathing were smaller for all pseudo-diffusion related parameters. Breath-holding is time inefficient, and free-breathing allows more data collection for development of robust DWI markers.

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