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Abstract #3482

Hemispheric asymmetries and grey matter projections of the arcuate fasciculus: an along-tract study of diffusion and localization properties with deterministic and probabalistic tractography

Lia Talozzi1, Claudia Testa1, Stefano Zanigni1, Stefania Evangelisti1, Laura Ludovica Gramegna1, Claudio Bianchini1, Paola Fantazzini2,3, Caterina Tonon1, David Neil Manners1, and Raffaele Lodi1

1Department of Biomedical and NeuroMotor Sciences, University of Bologna and Functional MR Unit, Policlinico S. Orsola - Malpighi, Bologna, Italy, 2Department of Physics and Astronomy, University of Bologna, Italy, 3Centro Enrico Fermi, Roma, Italy

We studied the arcuate fasciculus in both cerebral hemispheres in 29 healthy subjects, by evaluating GM projections and along-tract diffusion properties and tract curvature, obtained with three tractography methods: probabilistic ball-and-sticks model, deterministic and probabilistic spherical deconvolution. In all subjects we detected the arcuate in both hemispheres. For all the tractography methods we measured a bigger tract volume on the left, but detected more tracts branching towards GM terminations on the left only with the probabilistic methods, that influenced both the tract curvature and its diffusion parameters. The probabilistic tractography methods better described arcuate connectivity, which is more complex in the left hemisphere.

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