Abstract #3483

Structural abnormalities in frontal lobe pathways in children with Attention-Deficit/Hyperactivity Disorder (ADHD)

Weining Wu^1,2, Hesham Hamoda², Lipeng Ning², Borjan Gagoski³, Kiera Sarill⁴, P. Ellen Grant⁵, Martha E. Shenton², Deborah Waber⁶, Nikos Makris², Gloria McAnulty⁴, and Yogesh Rathi²

¹College of Computer Science and Technology, Harbin Engineering University, Harbin, People's Republic of China, ²Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ³Department of Radiology, Children's Hospital of Boston, Boston, MA, United States, ⁴Department of Psychiatry, Children's Hospital of Boston, Boston, MA, United States, ⁵Fetal-Neonatal Neuroimaging and Developmental Science Center, Children's Hospital of Boston, Boston, MA, United States, ⁶Scientific Review and Behavioral Science Core, Children's Hospital of Boston, Boston, MA, United States

Structural abnormalities in frontal lobe connections have been observed in adults/children with ADHD in earlier studies using diffusion tensor imaging (DTI)³. This abstract investigates microstructural differences in frontal-lobe white matter connectivity using advanced diffusion imaging methods. 47 white matter fiber bundles connecting frontal areas as parcellated by Freesurfer were extracted using a novel whole-brain tractography algorithm^4,1, which allowed estimation of specific diffusion properties such as cellular volume and cellular density from advanced diffusion MRI (dMRI) data. After correcting for multiple comparisons, 6 significant white matter pathways were found to have lower cellular volume and density in ADHD compared to controls.

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